United States Patent: 7601513
نویسنده
چکیده
Methods for expressing a heteromeric taste receptor that responds to umami taste stimuli are provided. These methods comprise the co-expression of T1R1 and T1R3 nucleic acid sequences in a host cell that desirably also expresses a G protein that couples therewith, e.g., G.sub..alpha.15 and G.sub..alpha.16 or gustducin. In preferred embodiments, the host cells will be mammalian cells or Xenopus oocytes. These nucleic acid sequences are expressed constitutively or under inducible conditions. In preferred embodiments, the methods will yield mammalian cells that stably express a T1R1/T1R3 umami taste receptor under inducible conditions, e.g., HEK-293 cells that express G.sub..alpha.15. Inventors: Zoller; Mark (San Diego, CA), Li; Xiaodong (San Diego, CA), Staszewski; Lena (San Diego, CA), O'Connell; Shawn (Encinitas, CA), Zozulya; Sergey (San Diego, CA), Adler; Jon Elliot (San Diego, CA), Xu; Hong (San Diego, CA), Echeverri; Femando (Chula Vista, CA) Assignee: Senomyx, Inc. (San Diego, CA) Appl. No.: 10/725,473 Filed: December 3, 2003 Related U.S. Patent Documents Application Number Filing Date Patent Number Issue Date < TD> 10179373 Jun., 2002 7368285 < TD> 10035045 Jan., 2002 7241880 < TD> 09897427 Jul., 2001 6955887 < TD> 09799629 Mar., 2001 7244835 < TD> 60374143 Apr., 2002 < TD> 60372090 Apr., 2002 < TD> 60339472 Dec., 2001 < TD> 60331771 Nov., 2001 < TD> 60310493 Aug., 2001 < TD> 60304749 Jul., 2001 < TD> 60300434 Jun., 2001 < TD> Current U.S. Class: 435/69.1 ; 435/252.3; 435/471 Current International Class: C12P 21/06 (20060101); C12N 1/20 (20060101); C12N United States Patent: 7601513 http://patft.uspto.gov/...p=1&u=/netahtml/PTO/srchnum.htm&r=1&f=G&l=50&s1=7,601,513.PN.&OS=PN/7,601,513&RS=PN/7,601,513[09/11/2009 8:36:03] 15/74 (20060101) References Cited [Referenced By] U.S. Patent Documents 5993778 November 1999 Firestein et al. 6383778 May 2002 Zuker et al. 6540978 April 2003 Margolskee et al. 2002/0051997 May 2002 Zuker et al. 2002/0094551 July 2002 Adler 2002/0151052 October 2002 Chaudhari et al. 2002/0160424 October 2002 Adler et al. 2002/0168635 November 2002 Zuker et al. 2003/0008344 January 2003 Adler et al. 2003/0022278 January 2003 Zuker et al. 2003/0022288 January 2003 Zuker et al. 2003/0036089 February 2003 Wei et al. 2003/0040045 February 2003 Zuker et al. 2003/0054448 March 2003 Adler et al. 2003/0166137 September 2003 Zuker et al. 2004/0086877 May 2004 Lal et al. 2005/0106571 May 2005 Erlenbach et al. 2007/0105159 May 2007 Erlenbach et al. Foreign Patent Documents WO 00/06592 Feb., 2000 WO WO 00/06593 Feb., 2000 WO WO 01/64882 Sep., 2001 WO WO 01/66563 Sep., 2001 WO WO 01/83749 Nov., 2001 WO WO 03/025137 Mar., 2002 WO WO 02/064631 Aug., 2002 WO WO 03/001876 Jan., 2003 WO WO 2005/015158 Feb., 2005 WO
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